Comparison of <scp>Levitt's CO</scp> breath test and the <scp> ¹⁵ N </scp> ?glycine labeling technique for measuring the lifespan of human red blood cells

The red blood cell (RBC) lifespan is an important physiological indicator of clear significance in clinical research, used for the differential diagnosis various diseases such as anemia, compensatory phase hemolysis, and polycythemia. 15N-glycine labeling technique gold standard method determining RBC lifespans. However, usefulness this settings seriously hindered by several weeks required to complete analyses. Levitt's CO breath test another reliable lifespans, with a simpler protocol giving much faster results, making it more useful applications. We compared measuring human lifespan. investigated lifespans where each subject undertook both test. correlation between results from these two methods was analyzed. Eight ten subjects successfully completed study. values obtained were lower than those technique. determined significantly correlated, Pearson coefficient R = 0.98 (p < 0.05), while R2 linear regression equation 0.96. exhibits good performance labelling distinguishing healthy hemolysis. result suggests that quickly